The Collaborative Research Center is an interdisciplinary endeavor aiming to develop basic concepts and theories for dealing with “good” and “bad” uncertainty. The new insights are applied to unsolved problems in various fields of economics and the natural sciences, especially in biology and physics. The CRC consists of 18 projects, most of which are located at the Faculty of Mathematics, but also at the Center for Mathematical Economics, the Faculty of Physics, and the Faculty of Technology. The funding is provided by the German Research Foundation (DFG) and amounts to about 10 million Euro in the second funding period (2021-2025). In particular, it covers 12 PhD positions and 14 postdoc positions.